Introduction
Klebsiella pneumoniae (K. pneumoniae) is a significant hospital-acquired pathogen, with its resistance to β-lactam antibiotics posing a considerable global threat. High Prevalence Regions like Greece, Italy, Israel, and parts of…
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Using Mobile Health Tools to Predict Asthma Attacks in Children
A Canadian study published in the JIMR Research Protocols, looked at how mobile health technology could help predict asthma flare-ups in children and teens before they happen. The Mobile Health for Kids With Asthma (MoKA) study, led by a team of…
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TV tonight: Lauren Lyle heads to New Zealand in a stressful new thriller | Television
The Ridge
9pm, BBC Two
Lauren Lyle, the Karen Pirie star, gets stuck in to another meaty protagonist role in this stressful psychological thriller. Mia is an anaesthetist, and also a recovering alcoholic. After an event at the hospital threatens…
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Disruption of glial circadian rhythms linked to Alzheimer’s disease progression
Alzheimer’s disease is notorious for scrambling patients’ daily rhythms. Restless nights with little sleep and increased napping during the day are early indicators of disease onset, while sundowning, or confusion later in the day,…
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Prada Group continues solid performance in 9M 2025
Patrizio Bertelli, Prada Group Chairman and Executive Director, commented: “The consistency of our results, in a complex macroeconomic environment, confirms the strength of our brands and the validity of our strategy. With the one just closed, the Group has delivered 19 quarters of uninterrupted growth. We continue to focus on creativity, product excellence and craftsmanship as foundations for enduring relevance and long-term development. These principles guide us as we navigate an evolving landscape with confidence, discipline and responsibility.”
Andrea Guerra, Group Chief Executive Officer, added: “Our performance confirms the health of our brands and further solid, diligent execution by our teams. Prada accelerated versus the previous quarter; Miu Miu has maintained a sustained growth trajectory for 4 years, including in this quarter that was facing triple-digit comps. Despite a still challenging environment, we remain confident in our trajectory, focusing on products and experiences that spark emotional engagement, while further improving our speed and flexibility.”
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Tight at the top at The International Series Philippines
Sarit – fourth in SJM Macao Open, tied 11th in the Jakarta International Championship and tied ninth in Mercuries Taiwan Masters in his previous three starts on the Asian Tour – started on the back nine and made four birdies on his way out,…
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Artificial intelligence-assisted colonoscopy improves adenoma detection rates in routine colonoscopy practice: a single-center, retrospective, propensity score-matched study with concurrent controls | BMC Gastroenterology
This study aimed to evaluate the effectiveness of AI-assisted colonoscopy in a real-world setting. AI-assisted colonoscopy resulted in significantly higher ADRs and APCs compared to standard colonoscopy (ADR, 35.9% vs. 26.4%; APC, 0.69 vs. 0.43)….
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Evolutionary diversification and expressional profile of adrenergic receptors in the Pacific oyster Crassostrea gigas | BMC Genomics
Motiejunaite J, Amar L, Vidal-Petiot E. Adrenergic receptors and cardiovascular effects of catecholamines. Ann Endocrinol. 2021;82:193–7.
Nikishchenko V, Kolotukhina N, Dyachuk V. Comparative…
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‘She changed ballet’: Misty Copeland takes her final bow at retirement show | Ballet
Misty Copeland took one last spin on her pointe shoes Wednesday night, showered with golden glitter and bouquets as she retired from American Ballet Theatre after a trailblazing career in which she became an ambassador for diversity in an…
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Amazon apologises to customers impacted by huge AWS outage
Amazon Web Services (AWS) has apologised to customers impacted by Monday’s massive outage, after it knocked some of the world’s largest platforms offline.
Snapchat, Reddit and Lloyds Bank were among more than 1,000 sites and services reported to have gone down as a result of issues at the heart of the cloud computing giant’s operations in North Virginia, US on 20 October.
In a detailed summary of what caused the outage, Amazon said it occurred as a result of errors which meant its internal systems could not connect websites with the IP addresses computers use to find them.
“We apologise for the impact this event caused our customers,” the company said.
“We know how critical our services are to our customers, their applications and end users, and their businesses.
“We know this event impacted many customers in significant ways.”
While many platforms such as the online games Roblox and Fortnite were back up and running within a few hours of the outage, some services experienced prolonged downtime.
This included Lloyds Bank, with some customers experiencing issues until mid-afternoon, as well as US payments app Venmo and social media site Reddit.
The outage had a far-reaching impact – even reportedly disrupting the sleep of some smart bed owners.
Eight Sleep, which makes sleep “pods” with temperature and elevation options requiring an internet connection, said it would work to “outage-proof” its mattresses after some overheated and even got stuck in an inclined position.
Many experts said the outage showed how reliant tech is on Amazon’s dominance in the cloud computing sector, as a market largely cornered by AWS and Microsoft Azure.
The company said it would also “do everything we can” to learn from the event and improve its availability.
In its lengthy summary of Monday’s outage, Amazon said it came down to an issue in US-EAST-1 – its largest cluster of data centres which power much of the internet.
Critical processes in the region’s database which stores and manages the Domain Name System (DNS) records, allowing website URLs to be understood by computers, effectively fell out of sync.
According to Amazon, this triggered a “latent race condition” – or in other words unearthed a dormant bug that could occur in an unlikely sequence of events.
The delay in one process, which Amazon said occurred in the early hours of Monday morning, had a knock-on effect which caused its systems to stop working properly.
Much of this process is automated, meaning it is done without human involvement.
Dr Junade Ali, a software engineer and fellow at the Institute for Engineering and Technology, told the BBC “faulty automation” had been at the core of Amazon’s problems.
“The specific technical reason is a faulty automation broke the internal ‘address book’ systems in that region rely upon,” he said.
“So they couldn’t find one of the other key systems.”
Like others, Dr Ali believes it highlights the need for companies to be more resilient and diversify their cloud service providers “so they can fail over to other data centres and providers when one isn’t available”.
“In this instance, those who had a single point of failure in this Amazon region were susceptible to being taken offline,” he said.
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